Kisspeptin 10mg Peptides 99% Purity Kisspeptin Raws
Product Name: Kisspeptin (10mg)
Synonyms: K-10mg, KISS-1, Protein KISS-1, metastin, Kp-10 peptide
Specifications: 10 vials per kit/box
Purity: 99%
Molecular formula: C63H83N17O14
Molecular weight: 1302.4 g/mol
Appearance: White lyophilized powder
Package: Discreet and secure
Shipping: Safety and fast, guarantee delivery
Storage: Lyophilized peptides to be stored below -18°C
Research use only. Not for human or animal consumption!
What is Kisspeptin?
Kisspeptin is a naturally occurring peptide protein encoded by the KISS1 gene in the human body (2).
Kisspeptin is a product of the KISS1 gene, which is produced due to the cleavage of the original 145 amino acid peptide to a smaller peptide composed of 54 amino acids (6).
KISS1 is a gene that suppresses metastases of the melanomas and breast carcinomas, thereby inhibiting abnormal cell growth and preventing cancer (2).
Initially thought to be a metastasis suppressor, Kisspeptin was later discovered to possess a different expression profile which also allows it to function on the hypothalamus and pituitary gland, and thereby positively affect the reproductive system (3).
How Does Kisspeptin Work?
GPR54, also called KISS1 receptor (KISS1R)(7), is an important GnRH receptor, which plays an important role in mammals for puberty to occur (5).
Kisspeptin binds to these GPR54 receptors that activate the reproductive axis by stimulating the release of GnRH and gonadotropin neurons in the body. By centrally applying Kisspeptin in the body (i.e., in the central nervous system), it stimulates more than 85% of GnRH neurons, which thereby secrete FSH and LH in the body (7).
As stated above, Kisspeptin is a 54 amino acid peptide product of the KISS1 gene. Besides this, there are other smaller peptide fragments such as Kisspeptin 10, 13, and 14, which all have a biological activity towards GPR54 (7). These smaller peptides bind with a low affinity to the GPR54 receptors and stimulate calcium mobilization, arachidonic acid release, and extracellular protein kinase phosphorylation (7). These events depolarize the Kisspeptin neurons, which leads to the depolarization of the GnRH neurons and thereby modulates the gonadotropin release (9).
In humans, GPR54 is expressed in the pituitary gland and in GnRH neurons, and Kisspeptin stimulates the release of GnRH through direct stimulation of the GnRH neurons and not through pituitary stimulation.
Kisspeptin is the most potent and effective peptide, which excites a vast majority of the GnRH neurons (7) and thereby regulates the reproductive system.
Clinical Uses of Kisspeptin
Reports show that Kisspeptin is a key regulator of the reproductive functions in both animals and humans, throughout their life.
Kisspeptin is a key regulator because of its following advantages (8):
Stimulates GnRH release in healthy human candidates and animals
Stimulates endogenous gonadotropin release in lesser fertile candidates
High dose administration of the peptide causes desensitization and suppression of the hypothalamus, pituitary gland, and gonadal axis
Possesses the potency to act differently during different phases of the reproductive life cycle (puberty, fertility, pregnancy, and menopause)
These factors make Kisspeptin a promising candidate to treat reproductive disorders and ailments dependent on sex hormones.
As the key regulator, Kisspeptin can also be used to treat the following conditions (9):
Delayed onset of puberty
Subfertility
GnRH deficiency
Contraception
Treatment of tumors related to the use of sex steroids
Treatment of metastatic carcinoma
Summary
Kisspeptin is a by-product of the KISS1 gene naturally found in the human system. Originally thought to inhibit the metastasis development in the body, Kisspeptin was later discovered to have a significant impact on the reproductive axis and regulates the secretion of gonadotropins in the body – primarily via binding to the GRP54 receptors.
Studies so far have demonstrated that this peptide protein has a significant effect on the reproductive system in humans. While the results are varied amongst women (depending on the phases of their menstrual cycle) and children with delayed puberty, the results so far seem promising with minimal side effects. It should be noted that impaired Kisspeptin levels can have significant adverse effects, especially in women, leading to increased body weight and weakened glucose regulation.
Since the breakthrough discovery of the correlation between Kisspeptin and reproductive axis is relatively new, clinical trials are still underway to fully explore the potency of this peptide and thereby potentially establish its use as a therapeutic agent in treating common reproductive disorders.
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